Abstract
A new clerodane diterpene, 15-hydroxy-16-acetoxy-ent-clerod-3-en-18-oic acid (1), together with three known clerodane diterpenes (2-4) and three known flavones (5-7), were isolated from the aerial parts of Baccharis gaudichaudiana. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Baccharis / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Diterpenes, Clerodane / isolation & purification
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Diterpenes, Clerodane / pharmacology*
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Molecular Structure
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Nerve Growth Factor / pharmacology
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Neurites / drug effects*
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PC12 Cells
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Plant Components, Aerial / chemistry*
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Rats
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Spectrum Analysis
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Diterpenes, Clerodane
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Flavonoids
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Nerve Growth Factor