Abstract
Nitric oxide prodrugs derived from hindered secondary amines were prepared. The decomposition patterns of these prodrugs indicate that alpha-methyl groups around the nitrogen bearing the diazeniumdiolate group prolong their half-life in aqueous buffer.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, N.I.H., Intramural
MeSH terms
-
Amines / chemistry*
-
Azo Compounds / chemistry*
-
Molecular Structure
-
Nitric Oxide / chemistry*
-
Prodrugs / chemistry*
Substances
-
Amines
-
Azo Compounds
-
Prodrugs
-
diazeniumdiolate
-
Nitric Oxide