Loss of T-bet sends host-microbe mutualism awry

Cell. 2007 Oct 5;131(1):15-7. doi: 10.1016/j.cell.2007.09.030.

Abstract

Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system.

Publication types

  • Comment

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • Colitis, Ulcerative / immunology*
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Homeostasis*
  • Humans
  • Immunity, Innate / physiology*
  • Intestines* / immunology
  • Intestines* / microbiology
  • Mice
  • Mice, Knockout
  • T-Box Domain Proteins / genetics
  • T-Box Domain Proteins / metabolism*
  • T-Lymphocytes / immunology
  • T-bet Transcription Factor
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Homeodomain Proteins
  • T-Box Domain Proteins
  • T-bet Transcription Factor
  • Tumor Necrosis Factor-alpha
  • RAG-1 protein