Nonsteroidal anti-inflammatory drug is usefulness, but it was well known that have often complicated gastric ulcers. Proton pump inhibitors (PPI) have gained worldwide popularity for the suppression of gastric acid production. PPI is used and shows most efficacies for gastric ulcer. In this paper we would like to discuss about prevention and treatment of nonsteroidal anti-inflammatory drug-induced gastric ulcers with PPI.