Objective: To investigate the expression and significance of CD133, Glut-1 and precursor cell, placental microvessel endothelial cells in the occurrence, development and regression of infantile hemangiomas.
Methods: We examined the expression and significance of CD133, Glut-1 in the occurrence, development and regression of infantile hemangiomas and congenital vascular malformation postnatal vascular malformation using immunohistochemical technique. An image analysis system (Image-pro plus 5.0) was used to measure the average integrated optical density and the rate of positive area of CD133 and Glut-i in different stages of hemangiomas and in vascular malformation.
Results: The expression of CD133 was significantly higher in differential stages congenital hemangioma, congenital vascular malformation, placenta chorionic villi than postnatal vascular malformation (P < 0.05). About the expression of Glut-1, there was difference between proliferating hemangiomas, placenta and degenerating hemangiomas, vascular malformation (P < 0.05).
Conclusion: The precursor cells marked CD133 is the source of endothelial cells derived from congenital hemangiomas and congenital vascular malformation.