Spinal epidural abscess is a rare clinical entity, presenting insidiously with nonspecific clinical manifestations. The diagnosis is usually difficult and, if not made early, the consequences may be disastrous. The therapeutic strategy consists of surgical drainage and systemic antibiotherapy for 4 to 6 weeks; in carefully selected patients, the surgical intervention may be avoided. We describe the case of a diabetic woman who presented with a spinal epidural abscess due to Streptococcus equi subsp. zooepidemicus, a group C Streptococcus, treated successfully with parenteral antibiotherapy followed by oral antibiotherapy. Group C streptococci are bacteria typically associated with disease in animals, nowadays emerging as important human pathogens. This is the first reported case of spinal epidural abscess due to a Group C Streptococcus.