A middle aged woman was operated with a locally advanced rectosigmoid cancer (GII,T4Nx). A potentially curative (R0) rectosigmoidal resection was carried out along with a partial excision of the abdominal wall, due to tumour invasion. The abdominal wall was reconstructed with three Gore Micromesh Plus meshes that were sutured together, and fixed to the rest of the abdominal wall and to the symphysis distally. As part of the abdominal wall reconstruction, bilateral rectus femoris musculocutaneous neurovascular flap was applied. At six month follow-up, the patient was in good health, and she was able to carry out her routine tasks. There was no locoregional or systemic recurrence detected.