Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver

FEBS Lett. 2007 Oct 30;581(26):5029-33. doi: 10.1016/j.febslet.2007.09.038. Epub 2007 Sep 29.

Abstract

Plasma high density lipoprotein (HDL)-cholesterol levels are inversely correlated with the incidence of cardiovascular diseases. HDL is mainly assembled in the liver through the ATP-binding cassette transporter (ABCA1) pathway. In humans, plasma HDL-cholesterol levels are positively correlated with plasma adiponectin (APN) concentrations. Recently, we reported that APN enhanced apolipoprotein A-I (apoA-I) secretion and ABCA1 expression in HepG2 cells. In the present study, we investigated HDL assembly in APN-knockout (KO) mice. The apoA-I protein levels in plasma and liver were reduced in APN-KO mice compared with wild-type-mice. The ABCA1 expression in liver was also decreased in APN-KO mice. APN deficiency might cause the impaired HDL assembly by decreasing ABCA1 expression and apoA-I synthesis in the liver.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Adiponectin / genetics
  • Adiponectin / physiology*
  • Animals
  • Apolipoprotein A-I / blood
  • Apolipoprotein A-I / metabolism*
  • Lipoproteins, HDL / blood
  • Lipoproteins, HDL / metabolism*
  • Lipoproteins, VLDL / blood
  • Liver / metabolism*
  • Mice
  • Mice, Knockout

Substances

  • ABCA1 protein, human
  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters
  • Adiponectin
  • Apolipoprotein A-I
  • Lipoproteins, HDL
  • Lipoproteins, VLDL