Abstract
A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chromatography, High Pressure Liquid
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DNA Primers
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Furans / chemical synthesis*
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Furans / pharmacology*
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HIV Integrase Inhibitors / chemical synthesis
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HIV Integrase Inhibitors / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
Substances
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DNA Primers
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Furans
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HIV Integrase Inhibitors