Abstract
Eleven new indole alkaloids, in addition to the previously reported rhazinal (1), and 14 other known alkaloids, were obtained from the Malayan Kopsia singapurensis, viz., kopsiloscines A-F (2-7), 16-epikopsinine (8), kopsilongine- N-oxide (9), 16-epiakuammiline (10), aspidophylline A (11), and vincophylline (12). The structures of these alkaloids were determined using NMR and MS analyses. Rhazinal (1), rhazinilam (17), and rhazinicine (18) showed appreciable cytotoxicity toward drug-sensitive as well as vincristine-resistant KB cells, while kopsiloscines A (2), B (3), and D (5) and aspidophylline A (11) were found to reverse drug-resistance in drug-resistant KB cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / classification
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Drug Resistance, Multiple / drug effects
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Drug Resistance, Neoplasm / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Indolizines / chemistry
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Indolizines / isolation & purification
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Indolizines / pharmacology
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KB Cells
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Lactams / chemistry
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Lactams / isolation & purification
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Lactams / pharmacology
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Malaysia
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Molecular Structure
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Plants, Medicinal / chemistry*
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Indolizines
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Lactams
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rhazinilam