[A case of gastric cancer with severe lymph node metastasis effectively treated with docetaxel / S-1 as neoadjuvant chemotherapy]

Gan To Kagaku Ryoho. 2007 Oct;34(10):1643-6.
[Article in Japanese]

Abstract

A 75-year-old male patient had advanced gastric cancer with severe lymph node metastasis. He was treated with docetaxel 60 mg/body (day 1) and S-1 120 mg/body (2 weeks administration and 1 week rest) as neoadjuvant chemotherapy. After two courses of this neoadjuvant chemotherapy, the primary lesion and lymph node swelling were remarkably improved. The patient underwent total gastrectomy and D2 lymph node dissection. The histological effect was judged to be Grade 3, and no viable cancer cell was detected in the primary lesion and lymph node (pCR). Docetaxel and S-1 combination therapy were thought to be an effective method as neoadjuvant chemotherapy for advanced gastric cancer with severe lymph node metastasis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antimetabolites, Antineoplastic / administration & dosage*
  • Chemotherapy, Adjuvant*
  • Docetaxel
  • Drug Combinations
  • Humans
  • Lymphatic Metastasis*
  • Male
  • Neoadjuvant Therapy*
  • Oxonic Acid / administration & dosage*
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery
  • Taxoids / administration & dosage*
  • Tegafur / administration & dosage*

Substances

  • Antimetabolites, Antineoplastic
  • Drug Combinations
  • Taxoids
  • S 1 (combination)
  • Tegafur
  • Docetaxel
  • Oxonic Acid