Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A

J Am Chem Soc. 2007 Nov 14;129(45):13812-3. doi: 10.1021/ja076197d. Epub 2007 Oct 18.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Binding Sites
  • Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
  • Models, Molecular
  • Molecular Conformation
  • Molecular Weight
  • Peptide Library*
  • Protein Kinase Inhibitors / chemistry*
  • Protein Kinase Inhibitors / pharmacology
  • Protein Structure, Tertiary
  • Staurosporine / chemistry*
  • Staurosporine / pharmacology
  • Structure-Activity Relationship

Substances

  • Peptide Library
  • Protein Kinase Inhibitors
  • Cyclic AMP-Dependent Protein Kinases
  • Staurosporine