Abstract
We present the development and performance characteristics of a free-space fluorescence tomography system. The imaging system can capture complete angle projections of photons propagating through tissue in transillumination using a CCD camera. Experimental data on imaging lung cancer are presented. Overall, this imaging approach can offer unprecedented imaging performance in fluorescence molecular tomography of small animals.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
MeSH terms
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Algorithms
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Animals
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Equipment Design
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Equipment Failure Analysis
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Image Enhancement / instrumentation
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Image Interpretation, Computer-Assisted / instrumentation*
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Imaging, Three-Dimensional / instrumentation*
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Lung Neoplasms / pathology*
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Mice
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Microscopy, Fluorescence / instrumentation*
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Molecular Probe Techniques / instrumentation*
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Reproducibility of Results
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Sensitivity and Specificity
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Signal Processing, Computer-Assisted
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Tomography, Optical / instrumentation*
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Whole Body Imaging / instrumentation*
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Whole Body Imaging / methods