Simulated mossy fiber associated feedforward circuit functioning as a highpass filter

Conf Proc IEEE Eng Med Biol Soc. 2006:2006:4979-82. doi: 10.1109/IEMBS.2006.260702.

Abstract

Learning and memory rely on the strict regulation of communication between neurons in the hippocampus. The mossy fiber (MF) pathway connects the dentate gyrus to the auto-associative CA3 network, and the information it carries is controlled by a feedforward circuit combining disynaptic inhibition with monosynaptic excitation. Analysis of the MF associated circuit using a mapped clock oscillator (MCO) model reveals the circuit to be a highpass filter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Cerebellar Cortex / pathology*
  • Dentate Gyrus / pathology*
  • Electrophysiology
  • Equipment Design
  • Hippocampus / pathology*
  • Humans
  • Long-Term Potentiation
  • Models, Neurological
  • Models, Statistical
  • Neurons / pathology*
  • Oscillometry / methods
  • Software
  • Synaptic Transmission
  • Time Factors