Choice of first antihypertensive--are existing guidelines ignored?

Br J Clin Pharmacol. 2007 Dec;64(6):722-5. doi: 10.1111/j.1365-2125.2007.03005.x. Epub 2007 Oct 22.

Abstract

Aims: To determine adherence to hypertension guidelines in relation to age and diabetes.

Methods: The Irish HSE-PCRS prescribing database identified patients initiating antihypertensive monotherapy in 2005. Logistic regression predicted the likelihood of therapy according to guidelines.

Results: The odds ratio (OR) of receiving therapies according to the guideline recommendations in those <55 years vs. > or =55 years was 1.31 (95% CI 1.26, 1.37). Diabetics were more likely than nondiabetics to receive antihypertensives other than beta-adrenoceptor blockers (OR 2.97, 95% CI 2.74, 3.21).

Conclusions: Our findings show some adherence to the guidelines in relation to age but selective prescribing of antihypertensives for diabetics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Factors
  • Antihypertensive Agents / pharmacokinetics
  • Antihypertensive Agents / therapeutic use*
  • Choice Behavior*
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / metabolism
  • Guideline Adherence / standards*
  • Humans
  • Hypertension / drug therapy
  • Hypertension / epidemiology
  • Hypertension / metabolism
  • Practice Guidelines as Topic / standards*

Substances

  • Antihypertensive Agents