Hepatitis C virus viral load after conversion from tacrolimus to cyclosporine in liver transplant patients: a pilot study

Transplant Proc. 2007 Oct;39(8):2603-5. doi: 10.1016/j.transproceed.2007.08.086.

Abstract

We assessed whether conversion from tacrolimus (TAC) to cyclosporine (CsA) was associated with a reduction in hepatitis C virus (HCV) viral load among HCV-positive liver transplant (OLT) patients.

Patients and methods: Nine OLT patients with recurrent HCV have TAC and prednisone immunosuppression. None received any HCV antiviral therapy. After the last intake of TAC, the patients underwent a 12-hour area under the curve (AUC(12)) measurement of both TAC and HCV viral loads. The next morning (D(0)) patients were given CsA (4 mg/kg bid). At the first intake of CsA and at 1 month (M(1)) later, the patients underwent AUC(12) for CsA and HCV viral loads. Biological data, including aspartate (AST) and alanine (ALT) aminotransferase, gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), and bilirubin levels, were collected during AUC(12), and at M(1) and M(3).

Results: With respect to liver enzymes (AST, ALT, GGT), there was no significant difference between D(0), M(1), and M(3). Conversely, there was a significant decrease in AP between D(0) and M(3) (P = .02), and a significant increase in total bilirubin between D(0) and M(1) (P = .04), and between D(0) and M(3) (P = .01). HCV viral load significantly increased by M(3) (P = .01). At no time (D(0), M(1)) was there any correlation between the AUC(12) of TAC or CsA, and between AUC(12) HCV viral load.

Conclusion: This pilot study found no acute or chronic anti-HCV effects from CsA that were evident within 12 hours after CsA administrations or beyond 1 month of CsA therapy, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alkaline Phosphatase / blood
  • Cyclosporine / blood
  • Cyclosporine / therapeutic use*
  • Hepacivirus / isolation & purification*
  • Hepatitis C / diagnosis*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Liver Function Tests
  • Liver Transplantation / immunology*
  • Middle Aged
  • Pilot Projects
  • Prednisone / therapeutic use
  • RNA, Viral / blood*
  • Tacrolimus / blood
  • Tacrolimus / therapeutic use*
  • Viral Load*

Substances

  • Immunosuppressive Agents
  • RNA, Viral
  • Cyclosporine
  • Alkaline Phosphatase
  • Prednisone
  • Tacrolimus