Objective: The aim was to present the 20-years experiences of medical care of children borne to HIV(+) mothers and HIV infected children.
Methods: Between 1987 and 2006 year 305 children borne to HIV(+) mother were investigated. The risk of vertical transmission was estimated. We analyzed routs of HIV transmission, the reasons of HIV diagnosis, HIV staging at diagnosis, HBV and HCV coinfection, ART treatment and its efficacy.
Main observations and results: HIV infection was confirmed: 75 cases of vertical HIV infection and 8 children infected in other ways. 260 children were borne after 1994 year (the date of introducing recommendation of the use of ART to reduce perinatal transmission of HIV). 158 of them received prophylaxis of vertical HIV infection. The risk of HIV vertical in children receiving prophylaxis was 5% comparing to 45.6% risk in children without prophylaxis regimens. 66 children receive ART regimen. The efficacy of treatment was: viral 85%, immunological: 89% and clinical: 85% improvement.
Conclusions: HIV testing should be offered to every women in the child-bearing age. Current prophylaxis, which suppress maternal VL HIV below detection level, decrease the risk of vertical HIV transmission to 0-1%. The child born to HIV(+) mother requires early diagnostics of HIV, HBV, HCV infections. Because of rapid progression of the disease, the HIV infected child should be diagnosed and treated since the first year of life. Properly treated children reach to mature age.