Action of endogenous prostaglandins on postprandial pyloric motility: a possible modulation by fats

Prostaglandins. 1991 Oct;42(4):313-20. doi: 10.1016/0090-6980(91)90080-y.

Abstract

The involvement of endogenous prostaglandins (PGs) and the effect of exogenous PGs on the myoelectrical activity of the pylorus were examined for 6 hours after a meal in dogs chronically fitted with intraparietal electrodes on the gastroduodenal junction. The animals received either a standard meal or a fat meal which consisted of canned food added or not (standard meal) with arachis oil. The cyclooxygenase inhibitors, indomethacin (1 mg/kg) and piroxicam (0.2 mg/kg) given prior a fat meal significantly increased the frequency of pyloric spike bursts but did not modify the pyloric motility associated with a standard meal. Synthetic derivatives of PGE1 (misoprostol, 5-10 micrograms/kg) or PGE2 (enprostil 0.5-1 micrograms/kg) reduced the frequency of pyloric contractions after a fat but not a standard meal. It is suggested that both endogenous and exogenous prostaglandins may modulate postprandial pyloric motility when fats are present in sufficient amount into the meal.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Animals
  • Diet
  • Dietary Fats / pharmacology*
  • Dogs
  • Duodenum / drug effects
  • Electromyography
  • Enprostil / pharmacology
  • Gastrointestinal Motility / drug effects*
  • Indomethacin / pharmacology
  • Misoprostol / pharmacology
  • Piroxicam / pharmacology
  • Prostaglandin-Endoperoxide Synthases / physiology*
  • Pyloric Antrum / drug effects
  • Pylorus / drug effects*
  • Time Factors

Substances

  • Dietary Fats
  • Misoprostol
  • Piroxicam
  • Prostaglandin-Endoperoxide Synthases
  • Enprostil
  • Indomethacin