Abstract
Microbial pathogens have developed various stratagems for modulating and/or circumventing the host's innate and adaptive immunity. Hence, certain virulence factors can be viewed as potential therapeutic agents for human immunopathological diseases. This is the case for virulence plasmid-encoded proteins from pathogenic Yersiniae that inhibit the host's inflammatory response by interfering with various cellular signaling pathways.
MeSH terms
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Animals
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology
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Colitis / immunology
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Colitis / prevention & control
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Humans
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Inflammation / immunology
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Inflammation / therapy*
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Inflammatory Bowel Diseases / immunology
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Inflammatory Bowel Diseases / therapy
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Lactococcus lactis / genetics
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Lactococcus lactis / immunology
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Mice
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Pore Forming Cytotoxic Proteins / genetics
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Pore Forming Cytotoxic Proteins / immunology
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Trinitrobenzenesulfonic Acid / toxicity
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Virulence Factors / therapeutic use*
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Yersinia / genetics
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Yersinia / immunology*
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Yersinia / pathogenicity
Substances
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Antigens, Bacterial
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LcrV protein, Yersinia
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Pore Forming Cytotoxic Proteins
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Virulence Factors
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Trinitrobenzenesulfonic Acid