Abstract
Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3'-azido-3'-deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / pharmacology*
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HIV-1 / drug effects*
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HIV-1 / physiology
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HIV-2 / drug effects*
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HIV-2 / physiology
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HeLa Cells
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Humans
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Microbial Sensitivity Tests / methods
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Reverse Transcriptase Inhibitors / pharmacology*
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Zidovudine / pharmacology*
Substances
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Anti-HIV Agents
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Reverse Transcriptase Inhibitors
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Zidovudine