Abstract
Toxic and magnetic resonance contrast characteristics of new nitroxyl radicals Fur-135 and Fur-176 were studied in experiments on mice. The test compounds exhibited low toxicity and allowed us to increase contrasting of transplanted RLS lymphoma. Fur-135 differs by the type of contrasting from Gd(3+)-containing preparation omniscan and locates the tumor focus with high precision.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Brain / pathology
-
Contrast Media / administration & dosage
-
Contrast Media / chemistry
-
Free Radicals / administration & dosage
-
Free Radicals / chemistry
-
Injections, Intravenous
-
Kidney / pathology
-
Liver / pathology
-
Lymphoma / pathology*
-
Magnetic Resonance Imaging / methods*
-
Male
-
Mice
-
Neoplasms, Experimental / pathology
-
Nitrogen Oxides / administration & dosage
-
Nitrogen Oxides / chemistry*
-
Reproducibility of Results
-
Spleen / pathology
Substances
-
Contrast Media
-
Free Radicals
-
Nitrogen Oxides
-
nitroxyl