Regio- and stereospecific formation of protected allylic alcohols via zirconium-mediated S(N)2' substitution of allylic chlorides

J Am Chem Soc. 2007 Nov 21;129(46):14144-5. doi: 10.1021/ja075967i. Epub 2007 Oct 31.

Abstract

A new, highly regio- and stereospecific SN2' substitution reaction between a zirconium oxo complex and allylic chloride has been achieved. The resulting allylic alcohol or TBS-protected allylic ether products were isolated in good to excellent yields with a wide range of E-allylic chlorides. A mechanism for the SN2' allylic substitution consistent with kinetic, stereochemical and secondary isotope effect studies was proposed.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Allyl Compounds / chemistry*
  • Hydrocarbons, Chlorinated / chemistry*
  • Models, Chemical
  • Propanols / chemical synthesis*
  • Zirconium / chemistry*

Substances

  • Allyl Compounds
  • Hydrocarbons, Chlorinated
  • Propanols
  • allyl alcohol
  • Zirconium