Central venous catheterization via the axillary vein was performed in 180 comatose patients with a success rate of 91%. The scarcity of serious nervous (none), thrombotic (6%), hemorrhagic (9.4%), infectious (1.8%), or thoracic (none) complications, the preservation of cerebral venous drainage, a longer distance between puncture site and tracheostomy or intubation tube make this safe and easy procedure perfectly convenient for comatose patients.