Abstract
An extensive study of metabolites present in Euphorbia esula led to isolation of 16 ingenane diterpenoids 1-16 together with the known ingenane derivative 17 and four known cycloartane triterpenoids. Their structures were elucidated on the basis of spectroscopic studies and comparison with known related compounds. All the compounds were assayed for their inhibitory activity against human HeLa cervical cancer cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Proliferation / drug effects
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Euphorbia / chemistry*
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Euphorbia / metabolism
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HeLa Cells
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Humans
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Magnetic Resonance Spectroscopy / methods
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Magnetic Resonance Spectroscopy / standards
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Molecular Conformation
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Reference Standards
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Stereoisomerism