CSF hypocretin-1 levels are normal in multiple-system atrophy

W F Abdo; B R Bloem; H P H Kremer; G J Lammers; M M Verbeek; S Overeem

doi:10.1016/j.parkreldis.2007.08.012

CSF hypocretin-1 levels are normal in multiple-system atrophy

Parkinsonism Relat Disord. 2008;14(4):342-4. doi: 10.1016/j.parkreldis.2007.08.012. Epub 2007 Oct 31.

Authors

W F Abdo¹, B R Bloem, H P H Kremer, G J Lammers, M M Verbeek, S Overeem

Affiliation

¹ Institute of Neurology, Department of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P.O. Box 9101, 6500 Nijmegan, HB, The Netherlands.

PMID: 17977056
DOI: 10.1016/j.parkreldis.2007.08.012

Abstract

Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Case-Control Studies
Female
Humans
Intracellular Signaling Peptides and Proteins / cerebrospinal fluid*
Male
Middle Aged
Multiple System Atrophy / cerebrospinal fluid*
Multiple System Atrophy / classification
Neuropeptides / cerebrospinal fluid*
Orexins

Substances

HCRT protein, human
Intracellular Signaling Peptides and Proteins
Neuropeptides
Orexins