Synthesis and antitumor activity of amine analogs of irofulven

Trevor C McMorris; Ramesh Chimmani; Mahender Gurram; Michael D Staake; Michael J Kelner

doi:10.1016/j.bmcl.2007.10.040

Synthesis and antitumor activity of amine analogs of irofulven

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6770-2. doi: 10.1016/j.bmcl.2007.10.040. Epub 2007 Oct 17.

Authors

Trevor C McMorris¹, Ramesh Chimmani, Mahender Gurram, Michael D Staake, Michael J Kelner

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.

PMID: 17977722
DOI: 10.1016/j.bmcl.2007.10.040

Abstract

Acylfulvenes, a class of semisynthetic analogs of Illudin S, show high toxicity toward prostate cancer cells. Here we probe the effect of changes in hydrophilic character of the analogs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / pathology
Amines / chemistry*
Antineoplastic Agents, Alkylating / chemical synthesis*
Antineoplastic Agents, Alkylating / chemistry
Antineoplastic Agents, Alkylating / toxicity*
Cell Line, Tumor
Cell Survival / drug effects
Humans
Inhibitory Concentration 50
Molecular Structure
Sesquiterpenes / chemical synthesis*
Sesquiterpenes / chemistry
Sesquiterpenes / toxicity*
Structure-Activity Relationship

Substances

Amines
Antineoplastic Agents, Alkylating
Sesquiterpenes
irofulven