Comparison of the human immunodeficiency virus (HIV) type 1-specific immunoglobulin G capture enzyme-linked immunosorbent assay and the avidity index method for identification of recent HIV infections

J Clin Microbiol. 2008 Jan;46(1):341-5. doi: 10.1128/JCM.01055-07. Epub 2007 Oct 31.

Abstract

The sensitivity and specificity of the human immunodeficiency virus (HIV) type 1-specific immunoglobulin G capture enzyme-linked immunosorbent assay (BED-CEIA) were compared with those of the avidity index method to identify recent HIV infection using a panel of 148 samples (81 patients) representing durations of infection ranging from 0 to 222 weeks. The results from the two tests were similar (sensitivity of 80% versus 74% [P = 0.53]; specificity of 86% versus 82% [P = 0.67]).

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibody Affinity*
  • Enzyme-Linked Immunosorbent Assay / methods*
  • HIV Antibodies / blood*
  • HIV Infections / diagnosis*
  • HIV Infections / virology
  • HIV-1 / immunology*
  • Humans
  • Immunoglobulin G / blood*
  • Sensitivity and Specificity

Substances

  • HIV Antibodies
  • Immunoglobulin G