Cervical human papillomavirus (HPV) infection in South African women: implications for HPV screening and vaccine strategies

Bruce Allan; Dianne J Marais; Margaret Hoffman; Samuel Shapiro; Anna-Lise Williamson

doi:10.1128/JCM.01981-07

Cervical human papillomavirus (HPV) infection in South African women: implications for HPV screening and vaccine strategies

J Clin Microbiol. 2008 Feb;46(2):740-2. doi: 10.1128/JCM.01981-07. Epub 2007 Oct 31.

Authors

Bruce Allan¹, Dianne J Marais, Margaret Hoffman, Samuel Shapiro, Anna-Lise Williamson

Affiliation

¹ Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa.

Abstract

The prevalence of cervical human papillomavirus (HPV) in South African women (n = 1,073) increased from 20.4% (173/848) in women with normal cytology to 41.7% (48/115) in women with atypical squamous cells of undetermined significance, 70.2% (40/57) in women with low-grade squamous intraepithelial lesions, and 83% (44/53) in women with high-grade squamous intraepithelial lesions (HSILs). HPV types 16 and 35 were the dominant types in women with HSILs but not in women in the other categories.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Humans
Middle Aged
Papilloma / epidemiology
Papilloma / virology
Papillomaviridae / classification*
Papillomaviridae / isolation & purification*
Papillomavirus Infections / epidemiology*
Papillomavirus Infections / pathology
Papillomavirus Infections / virology*
Precancerous Conditions / epidemiology
Precancerous Conditions / virology
Prevalence
South Africa / epidemiology
Uterine Cervical Diseases / epidemiology*
Uterine Cervical Diseases / pathology
Uterine Cervical Diseases / virology*