Abstract
The aerial parts of Centaurea pullata afforded, in addition to the previously isolated sesquiterpene lactones, 11beta,13-dihydrocnicin and 11beta,13-dihydro-19-desoxycnicin, three minor sesquiterpene lactones, namely, a new germacranolide, 8alpha-O-(4-acetoxy-5-hydroxyangeloyl)-11beta,13-dihydrocnicin, and two new eudesmanolides, 8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)-11beta,13-dihydrosonchucarpolide and 8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)-11beta,13-dihydro-4-epi-sonchucarpolide. The in vitro antimicrobial activity of all isolated sesquiterpene lactones was tested against six bacteria and eight fungal species, using a microdilution method. All compounds tested showed greater antibacterial and antifungal activities than the positive controls used.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Algeria
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology*
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Bacteria / drug effects
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Centaurea / chemistry*
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Fungi / drug effects
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology*
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Sesquiterpenes, Germacrane / chemistry
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Sesquiterpenes, Germacrane / isolation & purification*
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Sesquiterpenes, Germacrane / pharmacology*
Substances
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8alpha-O-(4-acetoxy-5-hydroxyangeloyl)-11beta,13-dihydrocnicin
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8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)-11beta,13-dihydro-4-epi-sonchucarpolide
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8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)-11beta,13-dihydrosonchucarpolide
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Anti-Bacterial Agents
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Antifungal Agents
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Lactones
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Sesquiterpenes
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Sesquiterpenes, Germacrane