Abstract
A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach. Antiplasmodial activity was evaluated on both chloroquino-resistant and -sensitive Plasmodium falciparum strains, and the selectivity indexes for THP1 and HepG2 human cells were also calculated, revealing their antiplasmodial potential.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemical synthesis*
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Antimalarials / pharmacology*
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Antimalarials / toxicity
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Cell Line
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Chloroquine / pharmacology
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Drug Resistance
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Humans
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Hydrocarbons, Chlorinated / chemical synthesis
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Hydrocarbons, Chlorinated / pharmacology
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Hydrocarbons, Chlorinated / toxicity
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Plasmodium falciparum / drug effects
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Quinazolines / chemical synthesis*
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Quinazolines / pharmacology*
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Quinazolines / toxicity
Substances
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Antimalarials
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Hydrocarbons, Chlorinated
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Quinazolines
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Chloroquine