Abstract
The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X 7 receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X 7-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Animals
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Australia
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification*
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Cytotoxins / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Purinergic P2 Receptor Antagonists*
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Receptors, Purinergic P2X7
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Tyrosine / analogs & derivatives*
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Tyrosine / chemistry
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Tyrosine / isolation & purification
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Tyrosine / pharmacology
Substances
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Alkaloids
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Cytotoxins
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P2RX7 protein, human
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Purinergic P2 Receptor Antagonists
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Receptors, Purinergic P2X7
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psammaplysene C
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psammaplysene D
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Tyrosine