Abstract
We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-beta-lactamase (VIM-1) and an extended-spectrum beta-lactamase (SHV-12). Time-kill studies demonstrated that the combination of both compounds was synergistic along the first 12 h, suppressing the regrowth observed after 3 to 6 h when colistin was tested alone.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Anti-Bacterial Agents / therapeutic use*
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Bacteremia / drug therapy*
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Colistin / therapeutic use
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Drug Synergism
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Drug Therapy, Combination
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Humans
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Klebsiella Infections / drug therapy*
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / enzymology
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Male
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Microbial Sensitivity Tests
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Microbial Viability
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Minocycline / analogs & derivatives*
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Minocycline / therapeutic use
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Tigecycline
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beta-Lactamases / biosynthesis*
Substances
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Anti-Bacterial Agents
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Tigecycline
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beta-Lactamases
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Minocycline
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Colistin