Abstract
Magnetic resonance imaging (MRI) of inflammation is based on the in vivo magnetic labelling of macrophages, the most abundant cells involved in the post-ischemic inflammatory response, by nanoparticles of iron oxides. Such approach has been successfully applied to study experimental rodent models of focal cerebral ischemia and has proved feasible in pioneer clinical studies. Despite current limitations, MRI of inflammation may become an important tool for the investigation of novel ischemic stroke therapeutics targeted at inflammation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Ischemia / diagnostic imaging*
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Brain Ischemia / metabolism
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Brain Ischemia / pathology
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Brain Ischemia / therapy
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Cerebrum / diagnostic imaging
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Cerebrum / metabolism
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Cerebrum / pathology
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Contrast Media / pharmacology*
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Disease Models, Animal
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Ferric Compounds / pharmacology*
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Inflammation / diagnostic imaging
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Inflammation / genetics
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Inflammation / metabolism
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Inflammation / therapy
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Macrophages / metabolism
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Macrophages / pathology
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Magnetic Resonance Imaging*
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Mice
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Mice, Knockout
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Nanoparticles*
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PPAR alpha / genetics
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PPAR alpha / metabolism
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PPAR-beta / genetics
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PPAR-beta / metabolism
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Radiography
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Stroke / diagnostic imaging*
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Stroke / genetics
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Stroke / metabolism
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Stroke / pathology
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Stroke / therapy
Substances
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Contrast Media
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Ferric Compounds
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PPAR alpha
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PPAR-beta
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ferric oxide