In vivo stimulation on rabbit retina using CMOS LSI-based multi-chip flexible stimulator for retinal prosthesis

Annu Int Conf IEEE Eng Med Biol Soc. 2007:2007:5791-4. doi: 10.1109/IEMBS.2007.4353663.

Abstract

We have performed in vivo electric stimulation experiments on rabbit retina to demonstrate feasibility of CMOS LSI-based multi-chip flexible neural stimulator for retinal prosthesis. We have developed new packaging structure with an improved flexibility and device control system which totally controls the LSI-based multi-chip stimulator, counter electrode, and stimulation generator. We have implanted the fabricated multi-chip stimulator into sclera pocket for STS (Suprachoroidal Transretinal Stimulation) configuration. We successfully obtained EEP (Electrically Evoked Potential) on visual cortex evoked by the multi-chip stimulator.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Differential Threshold
  • Electric Stimulation / instrumentation*
  • Electric Stimulation / methods
  • Electric Stimulation Therapy / instrumentation*
  • Electric Stimulation Therapy / methods
  • Equipment Design
  • Equipment Failure Analysis
  • Evoked Potentials, Visual / physiology*
  • Prostheses and Implants*
  • Rabbits
  • Reference Values
  • Retinal Ganglion Cells / physiology*
  • Semiconductors
  • Signal Processing, Computer-Assisted / instrumentation
  • Therapy, Computer-Assisted / instrumentation*
  • Therapy, Computer-Assisted / methods
  • Visual Cortex / physiology*