Abstract
The absolute stereo structure of the natural product laurenditerpenol (1S, 6R, 7S, 10R, 11R, 14S, 15R) has been accomplished from eight plausible stereoisomers by its first asymmetric total synthesis in a highly convergent and flexible synthetic pathway. Six stereoisomers of laurenditerpenol were synthesized and evaluated for their biological activity.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Cell Hypoxia
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Cell Line, Tumor
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Diterpenes / chemical synthesis*
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Diterpenes / chemistry
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Diterpenes / pharmacology
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Humans
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Hypoxia-Inducible Factor 1 / antagonists & inhibitors*
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Hypoxia-Inducible Factor 1 / biosynthesis
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Molecular Conformation
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Diterpenes
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Hypoxia-Inducible Factor 1
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laurenditerpenol