In general, the aging process of the face is a process of atrophy, most noticeable in the perioral region. This article discusses rejuvenation of the perioral region, including fillers, surgery, and facial resurfacing, as correction for this process. Detailed techniques for each of the approaches are outlined. Composition of the various fillers is discussed in conjunction with their respective outcomes and duration of effect. Clinical preoperative, intraoperative, and postoperative photographs are presented.