Abstract
Collapsin Response Mediator Protein (CRMP)-2 is involved in T-cell polarization and migration. To address the role of CRMP2 in neuroinflammation, we analyzed its involvement in lymphocyte recruitment to the central nervous system in mouse infected with neurotropic and non-neurotropic virus strains (RABV, CDV). A sub-population of early-activated CD69+CD3+ T lymphocytes highly expressing CRMP2 (CRMP2hi) peaked in the blood, lymph nodes and brain of mice infected with neurotropic viruses, and correlated with severity of disease. They displayed high migratory properties reduced by CRMP2 blocking antibody. These data point out the potential use of CRMP2 as a peripheral indicator of neuroinflammation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD / analysis
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Antigens, Differentiation, T-Lymphocyte / analysis
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Brain / immunology*
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Brain / pathology
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CD3 Complex / analysis
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Cell Movement
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Distemper / immunology*
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Encephalitis, Viral / immunology*
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Encephalitis, Viral / pathology
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Female
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Intercellular Signaling Peptides and Proteins / analysis
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Intercellular Signaling Peptides and Proteins / physiology*
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Lectins, C-Type
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Mice
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Mice, Inbred BALB C
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Nerve Tissue Proteins / analysis
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Nerve Tissue Proteins / physiology*
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Rabies / immunology*
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T-Lymphocytes / chemistry
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T-Lymphocytes / physiology*
Substances
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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CD3 Complex
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CD69 antigen
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Intercellular Signaling Peptides and Proteins
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Lectins, C-Type
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Nerve Tissue Proteins
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collapsin response mediator protein-2