Towards a synthesis of vigabatrin using glycal chemistry

Molecules. 2005 Aug 31;10(8):871-83. doi: 10.3390/10080871.

Abstract

Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored.

MeSH terms

  • Catalysis
  • Chemistry Techniques, Analytical / methods*
  • Magnetic Resonance Spectroscopy
  • Vigabatrin / chemical synthesis*
  • Vigabatrin / chemistry

Substances

  • Vigabatrin