Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution

Li Zhang; Beiying Qiu; Xin Li; Xin Wang; Jingya Li; Yongliang Zhang; Jian Liu; Jia Li; Jingkang Shen

doi:10.3390/11120988

Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution

Molecules. 2006 Dec 21;11(12):988-99. doi: 10.3390/11120988.

Authors

Li Zhang¹, Beiying Qiu, Xin Li, Xin Wang, Jingya Li, Yongliang Zhang, Jian Liu, Jia Li, Jingkang Shen

Affiliation

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China. [email protected]

Abstract

A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry
Dual-Specificity Phosphatases / antagonists & inhibitors*
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology*
Heterocyclic Compounds / chemistry
Humans
Microwaves*
Mitogen-Activated Protein Kinase Phosphatases / antagonists & inhibitors*
Models, Chemical*
Quinoxalines / chemical synthesis*
Quinoxalines / chemistry
Quinoxalines / pharmacology*

Substances

Amines
Enzyme Inhibitors
Heterocyclic Compounds
Quinoxalines
Mitogen-Activated Protein Kinase Phosphatases
DUSP22 protein, human
Dual-Specificity Phosphatases