RNA Pol IV plays catch with Argonaute 4

Susanne Till; Andreas G Ladurner

doi:10.1016/j.cell.2007.10.044

RNA Pol IV plays catch with Argonaute 4

Cell. 2007 Nov 16;131(4):643-5. doi: 10.1016/j.cell.2007.10.044.

Authors

Susanne Till¹, Andreas G Ladurner

Affiliation

¹ EMBL International PhD Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

PMID: 18022355
DOI: 10.1016/j.cell.2007.10.044

Abstract

Small-interfering RNAs regulate gene expression by affecting chromatin structure, transcription, translation, and RNA stability. In a recent report in Genes & Development, El-Shami et al. (2007) show that in plants, Argonaute 4-which is involved in RNA-directed DNA methylation-directly associates with RNA polymerase IVb through a repeat motif, establishing an intimate molecular link between RNAi and transcription.

MeSH terms

Animals
Arabidopsis / genetics
Arabidopsis / metabolism
Arabidopsis Proteins / genetics
Arabidopsis Proteins / metabolism*
Argonaute Proteins
DNA-Directed RNA Polymerases / genetics
DNA-Directed RNA Polymerases / metabolism*
Humans
RNA / genetics
RNA / metabolism
RNA Interference*
RNA, Small Interfering / metabolism
Transcription, Genetic*

Substances

AGO4 protein, Arabidopsis
Arabidopsis Proteins
Argonaute Proteins
RNA, Small Interfering
RNA
RNA polymerase IV, Arabidopsis
DNA-Directed RNA Polymerases