Abstract
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Benzothiazoles / chemical synthesis
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Benzothiazoles / chemistry
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Benzothiazoles / pharmacology*
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Cell Line, Tumor
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Humans
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Magnetic Resonance Spectroscopy
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Protein Kinase Inhibitors / chemical synthesis
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology*
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Proto-Oncogene Proteins c-raf / antagonists & inhibitors*
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Spectrometry, Mass, Electrospray Ionization
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Urea / chemical synthesis*
Substances
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Amides
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Benzothiazoles
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Protein Kinase Inhibitors
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Urea
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Proto-Oncogene Proteins c-raf