Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines

Haematologica. 2007 Oct;92(10):1431-2. doi: 10.3324/haematol.10874.

Abstract

We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent cause of failure (21.6%).

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anthracyclines / therapeutic use*
  • Brazil / epidemiology
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Humans
  • Leukemia, Promyelocytic, Acute / drug therapy*
  • Leukemia, Promyelocytic, Acute / epidemiology
  • Leukemia, Promyelocytic, Acute / pathology*
  • Male
  • Middle Aged
  • Treatment Outcome
  • Tretinoin / therapeutic use*

Substances

  • Anthracyclines
  • Tretinoin