Abstract
One new arylnaphthalene lignan named kadsuralignan H ( 1) and three new dibenzocyclooctadiene lignans, named kadsuralignans I ( 2), J ( 3), and K ( 4), respectively, were isolated from an EtOAc fraction of the 80% acetone extract of Kadsura coccinea. The structures were elucidated on the basis of spectroscopic evidence. Compound 1 is the second arylnaphthalene lignan isolated from the Kadsura genus. Compounds 1 and 3 showed inhibitory activity on nitric oxide (NO) production by the murine macrophage-like cell RAW264.7, which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (INF-gamma).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cyclooctanes / chemistry
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Cyclooctanes / isolation & purification*
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Cyclooctanes / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Interferon-gamma / pharmacology*
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Kadsura / chemistry*
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology*
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Lipopolysaccharides / pharmacology*
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Macrophages / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / biosynthesis*
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Plants, Medicinal / chemistry*
Substances
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Cyclooctanes
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Drugs, Chinese Herbal
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Lignans
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Lipopolysaccharides
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dibenzocyclooctadiene lignan
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Nitric Oxide
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Interferon-gamma