Abstract
Here, we describe the association of certain varicella-zoster virus (VZV) genotypes with unique glycoprotein E (gE) gene mutations. Within 45 analyzed VZV wild-type strains of genotypes A and D, five novel gE mutations were discovered. A statistically significant (P < 0.0001) association of certain gE mutations with VZV genotype D was found.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Chickenpox / virology
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Child
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Child, Preschool
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DNA, Viral / genetics
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Female
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Genotype
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Herpes Zoster / virology
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Herpesvirus 3, Human / classification*
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Herpesvirus 3, Human / genetics*
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Herpesvirus 3, Human / isolation & purification
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Humans
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Infant
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Male
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Middle Aged
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Mutation, Missense*
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Viral Envelope Proteins / genetics*
Substances
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DNA, Viral
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Viral Envelope Proteins
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glycoprotein E, varicella-zoster virus