Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells

Leukemia. 2008 Jun;22(6):1258-62. doi: 10.1038/sj.leu.2405023. Epub 2007 Nov 22.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects*
  • Caspase 3 / metabolism
  • Ceramides / biosynthesis*
  • Child
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Enzyme Activation / drug effects
  • Fenretinide / pharmacology
  • Humans
  • Imidazoles / pharmacology*
  • Nitric Oxide / antagonists & inhibitors
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / pharmacology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Reactive Oxygen Species / metabolism
  • Tumor Cells, Cultured

Substances

  • 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole
  • 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid
  • Ceramides
  • Imidazoles
  • Reactive Oxygen Species
  • Fenretinide
  • Nitric Oxide
  • Oleanolic Acid
  • bardoxolone methyl
  • Caspase 3