[Molecular phylogeny and genetic variability of echovirus 30 based on the analysis of the 3' end of the VP1 gene]

Ann Biol Clin (Paris). 2007 Nov-Dec;65(6):621-8.
[Article in French]

Abstract

Echovirus 30 represent one of the most frequently isolated enterovirus serotype, incriminated in various pathologies, essentially aseptic meningitis. Several works studied the molecular epidemiology of these viruses. By analysing a region of 260 nucleotides situated in the end of the VP1 gene (region regrouping the majority of the sequences of the Echovirus 30), we proposed to realise a synthesis work which regroup the main epidemiological studies on the Echovirus 30. We established a phylogenetic profile of 87 Echovirus strains geographically distinct and isolated during a half a century (1957-2003). The phylogentic tree permitted to distinguish 2 genogroups which the nucleotide divergence exceeds 20%. The 2 genogroups also present internal subdivisions named genotypes which the nucleotide divergence is more than 15%. Finally, we noted phylogenetic regroupings within a same genotype. The general profile of the phylogenetic tree is characterised by a distribution of the Echovirus 30 strains in the time independently of their geographically isolation, which reveals a genetic evolution of these viruses related to their high genetic plasticity and the rapid circulation from a geographic area to another.

Publication types

  • English Abstract

MeSH terms

  • Capsid Proteins / genetics*
  • Echovirus Infections / classification
  • Enterovirus B, Human / classification
  • Enterovirus B, Human / genetics*
  • Genetic Variation
  • Humans
  • Meningitis, Aseptic / virology
  • Phylogeny

Substances

  • Capsid Proteins