Abstract
The resistance of Mycobacterium tuberculosis (MBT) to fluoroquinolones is associated with the mutations concentrated in the gyrA gene that is a structural gene of a gyrase A subunit. Detection of mutations in this portion of the gene allows the sensitivity of MBT to this group of drugs to be rapidly determined.
MeSH terms
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / therapeutic use*
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DNA Gyrase / genetics*
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DNA Mutational Analysis
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Fluoroquinolones / administration & dosage
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Fluoroquinolones / pharmacology*
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Fluoroquinolones / therapeutic use*
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Humans
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics*
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Point Mutation / genetics*
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Tuberculosis, Pulmonary / drug therapy*
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Tuberculosis, Pulmonary / microbiology*
Substances
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Anti-Inflammatory Agents
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Fluoroquinolones
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DNA Gyrase