Abstract
Paraneoplastic cerebellar degeneration (PCD) is linked to an immune response against cerebellar degeneration related antigen 2 (cdr2) co-expressed in tumor and Purkinje neurons. Here, comprehensive immune-assessment assays were used to analyze CD8(+) T cells from 7 PCD patients, but no evidence was found of CD8(+) T cells specific for either of two previously described cdr2 epitopes (cdr2-1 and cdr2-2). In contrast, viral-specific CD8(+) T cells from healthy volunteers and PCD patients were measurable. These findings are inconsistent with an obligate role for cdr2-1- or cdr2-2-specific CD8(+) T cells in the pathogenesis of PCD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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CD8-Positive T-Lymphocytes / immunology*
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Female
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HLA-A2 Antigen / metabolism
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Humans
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Interferon-gamma / biosynthesis
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Lymphocyte Activation
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Lysosomal-Associated Membrane Protein 1 / analysis
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Middle Aged
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Nerve Tissue Proteins / immunology*
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Nerve Tissue Proteins / metabolism
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Paraneoplastic Cerebellar Degeneration / etiology
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Paraneoplastic Cerebellar Degeneration / immunology*
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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CDR2 protein, human
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HLA-A2 Antigen
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Lysosomal-Associated Membrane Protein 1
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Nerve Tissue Proteins
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Tumor Necrosis Factor-alpha
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Interferon-gamma