Abstract
We evaluated the in vitro activities of voriconazole, itraconazole, and terbinafine against 30 clinical isolates of Pythium insidiosum using a checkerboard macrodilution method. The combined activity of terbinafine plus itraconazole or plus voriconazole was synergic against 17% of the strains. Antagonism was not observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / pharmacology*
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Brazil
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Dog Diseases / microbiology
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Dogs
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Drug Synergism
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Horse Diseases / microbiology
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Horses
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Infections / microbiology
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Infections / veterinary
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Itraconazole / pharmacology*
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Microbial Sensitivity Tests / methods
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Naphthalenes / pharmacology*
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Pyrimidines / pharmacology*
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Pythium / classification
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Pythium / drug effects*
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Pythium / isolation & purification*
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Sheep
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Sheep Diseases / microbiology
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Terbinafine
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Triazoles / pharmacology*
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Voriconazole
Substances
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Antifungal Agents
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Naphthalenes
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Pyrimidines
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Triazoles
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Itraconazole
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Terbinafine
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Voriconazole