Abstract
Three new sesquiterpenoids, metachromins R--T (1--3), have been isolated from an Okinawan marine sponge Spongia sp. The structures and stereochemistry of 1--3 were elucidated on the basis of the spectroscopic data. Metachromins S (2) and T (3) showed modest cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Humans
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KB Cells
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Leukemia L1210 / drug therapy
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Mice
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Porifera / chemistry*
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Sesquiterpenes
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metachromin R
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metachromin S
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metachromin T